Investigation of Adenosine Deaminase, Aryl Esterase And Paraoxanaz-1 Serum Activities in Patients with Breast Cancer
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DOI:
https://doi.org/10.5281/zenodo.10431468Keywords:
ADA, ARE, Breast Cancer, PON-1Abstract
Aim: The purpose of the that study was to compare enzyme activities such as arylesterase (ARE), paraoxonase-1 (PON1), and adenosine deaminase (ADA) in patients with breast cancer. Materials and Methods: Adenosine deaminase (ADA), paraoxanase (PON-1) and arilesterase (ARE) activities were determined by spectrophotometer in the serums dissolved by centrifugation of blood samples from the patients with breast cancer. Results: The PON-1 activity of patient group (at phase-1, phase-2 and phase-3) was found significantly more lower than the healthy control group in breast cancerpatients (p<0.001). The serum ARE activity (at phase-1, phase-2 and phase -3) was found significantly morelower to control group in this thesis study (p<0.001). Then, in this study ADA activity was detected high in patient groups (at phase-1, phase -2 and phase -3) (p<0.001). Conclusion: In this study, the measurement of ARE, PON-I and ADA activities in breast cancer according to its stages in the literature is the first and a new study. As result, having a high level of PON-1 activity can be assessabled as a factor that reduces the risk of cancer that will be done.
References
R.T. Greenlee, T. Murray, S. Bolden, Cancer Statistics. Cancer J Clin.2000, 50, 7-33.
F. Ayhan, R. Yorgancıoğlu, Breast Cancer and Rehabilitatio). (Turkey Clinics J Int Med Sci). 2006, 2, 39–48.
P. Saip, S. Keskin, M. Özkan, M.A. Kaplan, F. Aydoğan, G.G. Demirağ, S. Uzunoğlu, H. Engin, G. Başaran, N. Güler, K. Uygun, B. Demirkan, F. Özdemir, E. Çubukçu, T. Salepçi, İ. Çiçin, Türkiye’de Meme Kanserli Hastaların Tanı Ve Tedavi Yöntemlerine Ulaşım Hızı; Çok Merkezli Gözlemsel Çalışma, 2011, 7, 2.
S. Shapiro, Does hormone replacement therapy cause breast cancer? Anapplication of causal principles to three studies: Part1. TheCollaborative Reanalysis.J. FamPlann Reprod Health Care.2011,37(2), 103-9.
B. Galanti, S. Nardiello, M. Russo, Fiorentino, F. Increased lymphocyte adenosine deaminase in typhoid fever. Scand J Infect Dis. 1981,13 (1), 47-50.
G. Sufrin, G.L. Tritsch, A. Mittelman, G.P. Murphy, Adenosine deaminase in patients with carcinoma of the bladder. J Urol,1978, 119, 343-6.
B. Halliwell, Drug antioxidant effects. Drugs.1991,42, (4), 569 – 605.
M. Yarıktaş, F. Döner, H. Doğru, Z. Aynalı Yönden, N. Delibaş, Baş Boyun Malign Tümörlerinde Malondialdehit düzeyleri ve Antioksidant enzim aktiviteleri (Malondialdehyde Levels and Antioxidant Enzyme Activities in Head and Neck Malign Tumors).Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi.200310, (4), 65 – 67.
M. Bilici, N. Cim, D. Demir, Investıgatıon of Levels Of OxıdatıveStres In Ovarıan Cancer Patıents.International Environmental Sciences Semposium of Van. 2014.
B. Halliwell, Drug antioxidant effects. Drugs. 1991, 42 ,(4), 569 - 605.
B. Ertürk, Akciğer Kanserli Hastalarda Malondialdehit (MDA) ve Total Antioksidan Kapasite (TAK) Düzeyi Ölçümü İle Oksidan-Antioksidan DengeninAraştırılması Turkish Republic Ministery of Health Süreyyapaşa Thoracic and Cardiovascular Diseases Training and Research Hospital, İstanbul.2006
M. Bilici, The Importance of Oxidative Stress in Early Week Pregnancy Losses. International Journal of Women's Health and Reproduction Sciences.2015,Vol;2
P.N.Durrington, B. Mackness, M.I. Mackness, Paraoxonase and Atherosclerosis. Arterio sclera Thromb Vasc Biol. 2001, 21, (4), 473-80.
M.I. Mackness, S. Arrol, P.N. Durrington, Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 1999,286, 152-154.
D.B. Rousselot, P. Therond, J.L. Beaudeux, J. Peynet, A. J. Delatre, High density lipoproteins and the oxidative hypothesis of atherosclerosis. 1991, 37, 939-949.
G. Paragh, L. Asztalos, I. Seres, Z. Balogh, L. Locsey, I. Karpati, Serum paraoxonase activity changes in uremic and kidney-transplanted patients.1999,83, 126-131.
E. Azarsız, E.Y. Sönmez, Paraoksonaz ve klinik önemi TürkBiyokimya Dergisi. 2000,25, 109-119.
M.I. Mackness, E. Peuchant, M.F. Dumon, C.H. Walker, M. Clerc, Absence of"A"-esterase activity in the serum of a patient with Tangier disease. ClinBiochem. 1989, 22, 475-478.
M.N. Akcay, M.F. Yilmaz, I.G. Akcay, Serum paraoxonase levels in pancreatic cancer. Hepato gastro enterology.2003,225-227.
M.N. Akcay, I.Yilmaz, M.F. Polat, G. Akcay, Serum paraoxonase levels in gastric cancer. Hepato gastro enterology. 2003, 273-275.
C. Caner, A.V. Özeç, A. Aydın, A. Topalkara, M.K. Arıcı, H. Erdoğan, M.İ. Toker , Diyabetik ve Diyabetik Olmayan Katarakt Hastalarında Humor Akozde ve Serumda Total OksidatifStres, Total Antioksidan Kapasite, Paraoksonaz, Arilesteraz ve Lipid peroksidaz Seviyelerinin Karşılaştırılması TJO. 2012, 42, 1.
F. Kobyahi, I. Ikeda, F. Muamo, Adenosine deaminazeisoenzymas in liver disease Amj. Gastroenteral. 1993, 88, 26-271.
O. Erel, Anovel automated direct measurement method for total antioxidant capacity using new generation, more stable ABTS radical cation. ClinBiochem. 2004,37,277-285.
O. Erel, A new automated colorimetric method for measuring total oxidant status. 2005,38 ,(12), 1103-11.
M. Bilici, N. Atasoy, S. Kavak, H. Demir, Examınıng the level of some elements (zınc, chromıum, Lead and cadmıum) and some lıver enzymes (lower And upper) ın the blood-serum of the workers at The car-reparıng shops ın the vıcınıty of van. Fresenius Environ mental Bulletin Vol 21/ No 4/ pages. 2012, 901 – 907.
H. Balcı, H. Genç, C. Papila, G. Can, B. Papila, H. Yanardağ, H Uzun, Serum lipid hydroperoxide levels and paraoxonase activity in patients with lung, breast, and colorectal cancer.2012, 26, 155–60.
M. Bilici, N. Atasoy, H. Demir, Examınıng the level of some elements (zınc, chromıum, Lead and cadmıum) and some lıver enzymes (lower And upper) ın the blood-serum of the workers at The car-reparıng shops ın the vıcınıty of van.2011.
C. Bobin – Dubigeon, B. Jaffre, M.P. Joalland, J.M. Classe, M. Campone, M. Hervé, J.M. Bard, Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence. 2012, 45 ,16-17, 1503-5.
R. Memişoğullar, KonuralpTıp Dergisi (Konuralp Medicine Journal). 20102,(2), 22-26.
E.T. Elkiran, N. Mar, B. Aygen, F. Gursu, A. Karaoglu, S. Koca, Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population.BMC Cancer. 2007, 7, 48.
M.N. Akcay, M.F. Polat, I. Yilmaz, G. Akcay, Serum paraoxonase levels in pancreatic cancer.Hepato gastroenterology. 2003, 225-227.
E.T.Elkiran, N. Mar, B. Aygen, F. Gursu, A. Karaoglu, S. Koca, Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population.BMC Cancer. 2007,7, 48.
Z.Q. Samra, S. Pervaiz, S. Şahin, N. Dar, M.A. Athar, Determination of oxygen derived free radicals producer (xanthine oxidase) and scavenger (paraoxonase1) enzymes and lipid parameters in different cancer patients.2011, 57 (9-10), 741-7.
D.T. Arioz, H. Camuzcuoglu, H. Toy, S. Kurt, H. Celik, O Erel, Paraoksanazın Endometrium kanseri ile ilişkisi. Eur J Gynaecol Oncol. 2009,30 (6),679-82.
D.T. Toy, S. Kurt, H. Celik, O. Erel, Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer.Gynecol Oncol. 2009, 112 (3), 481-5.
K. Çayır, M. Bilici, S.B. Tekin, F. Kara, A. Turkyılmaz, A. Yıldırım, Serum Paraoxonase and Arylesterase Activities in Esophageal Cancer.2010, 7 (4), 398-403.
U. Saracoğlu, O. Güven, I. Durak, Adenosine deaminase and 5’-nucleotidase activities in saliva from patients with oral and laryngeal cancer. Oral Diseases.2005, 11, 323-5.
M. Aghaei, F. Karami- Tehrani, S. Salami, M. Atri, Adenosine deaminase activity in the serum and malignant tumors of breast cancer: The assessment of isoenzyme ADA1 and ADA2 activities. Clin Biochem. 2008, 38, 887-91.
O, Canbolat, Ö. Akyol, M. Kavutçu, A.Ü. Işık, İ. Durak, Serum adenosine deaminase and total superoxide dismutase actvities before and after surgical removal of cancerous laryngeal tissue.1994,108, 849-51.
H. Lal, S.K. Munjal, U. Wig, A.S. Saini, Serum enzymes in head and neck cancer 3. J Laryngol Otol. 1987, 101, 1062-5.
İ. Durak, H. Perk, M. Kavutçu, Adenosine deaminase, 5’ nucleotidase, xantine oxidase, superoxide dismutase and catalase activities in cencerous and noncancerous human bladder tissues. Free RadicBiol Med. 1993, 16, 825-31.
K.S. Dasmahapatra, H.Z.K. Facs, A. Dasmahapatra, S. Suarez, Evaluation of adenosine deamase activity in patients with head and neck cancer. J Surg Res. 1986, 40, 363-73.
M.Aghaei, F. Karami-Tehrani, S. Salami, M. Atri, Diagnosticvalue of adenosine deaminase activity in benign and malignant breast tumors. 2010,41, (1), 14-8.
F. Al-Rubaye, T. Morad, Serum adenosine deaminase activity in Iraqi patients with breast cancer on tamoxifentherapy. 2012, 18 (3), 139-142.
N. Pirinççi, İ. Geçit, M. Güneş, M.B. Yüksel, M. Kaba, S. Tanık, H. Demir, M. Aslan, Serum adenozin deaminaz, katalaz ve mesane kanseri olan hastalarda karbonik anhidraz faaliyetleri. 2012, 67 (12),1443-6.
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