Investigation of Adenosine Deaminase, Aryl Esterase And Paraoxanaz-1 Serum Activities in Patients with Breast Cancer
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https://doi.org/10.5281/zenodo.10431468Keywords:
ADA, ARE, Breast Cancer, PON-1Abstract
Aim: The purpose of the that study was to compare enzyme activities such as arylesterase (ARE), paraoxonase-1 (PON1), and adenosine deaminase (ADA) in patients with breast cancer. Materials and Methods: Adenosine deaminase (ADA), paraoxanase (PON-1) and arilesterase (ARE) activities were determined by spectrophotometer in the serums dissolved by centrifugation of blood samples from the patients with breast cancer. Results: The PON-1 activity of patient group (at phase-1, phase-2 and phase-3) was found significantly more lower than the healthy control group in breast cancerpatients (p<0.001). The serum ARE activity (at phase-1, phase-2 and phase -3) was found significantly morelower to control group in this thesis study (p<0.001). Then, in this study ADA activity was detected high in patient groups (at phase-1, phase -2 and phase -3) (p<0.001). Conclusion: In this study, the measurement of ARE, PON-I and ADA activities in breast cancer according to its stages in the literature is the first and a new study. As result, having a high level of PON-1 activity can be assessabled as a factor that reduces the risk of cancer that will be done.
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